Services

Stem cells…….a hope for future medicine

Since last decades there have been several big advancements in the area of stem cells and regenerative medicine. This has made paradigm shift in the management of various advanced disease conditions using various kinds of stem cells.  Stem cells are very unique type of cells having tremendous potential of self-renewal and differentiation ability in various types of cells. Stem cells are highly proliferative in nature and have potential to regenerate the damaged/dysfunctional organs/tissues. Stem cells also provide structural and functional support to the failing organs. Due to these enormous valuable properties, stem cells have been considered as wonder cells in future regenerative medicine.

Visionary foundation of future medicine

“Padmashree” Prof. C. M. Habeebullah, first gastroenterologist in India pioneered stem cell-based treatments in India at Centre for Liver Research and Diagnostics, Hyderabad. His vision to support end-stage liver disease patients came true with stem cell-based supportive modality. However, much remained to accomplish his visionary approach using stem cell-based treatment strategies in several other kind of fatal disorders.

The visionary path shown by Prof. C. M. Habeebullah is being carried out at Dr Habeebullah Life Sciences which is a multidisciplinary organization harboring enormous two decades of research and clinical expertise in stem cells isolation, characterization and clinical applications in acute liver failure, liver cirrhosis and several other devastating conditions. The scientists at Dr Habeebullah Life Sciences trying to promote the applicability of stem cells and regenerative medicine in human health practices on highly scientific background.

Research and developments in stem cells and regenerative medicine

The centre is carrying out extensive high-end research and development in the field of stem cells and regenerative medicine wherein the primary focuses is to provide support to the patients with acute liver failure (ALF), end-stage liver diseases such as liver cirrhosis and also bridge the gap of liver transplantation as supportive modality. Furthermore, the centre is involved in developing future technologies such as:

• Whole organ bioengineering using stem cells
• Development of immune-tolerant biological scaffolds and
• Extra-corporeal organ devices using bioengineered organs

Furthermore, centre is also dedicated to imply stem cells in neurological disorders such as Parkinson, Alzheimer, amyotrophic lateral sclerosis, Duchene muscular dystrophy (DMD) and spinal cord injury (SCI), etc. The centre has pioneered biological neural conduits to regenerate the damaged spinal cords on permanent basis.

The centre has also developed gold nanoparticle-based safer drug-delivery systems to treat drug-resistant cancer cells at much lower dose with high efficacy and negligible systemic adverse reactions.

These emerging technologies have been patented and could revolutionize the field of stem cells and regenerative medicine in more scientific manner.

Probability of stem cell-based treatment strategies at Dr Habeebullah Life Sciences

• Currently, very few stem cell treatments have been proven safe and effective which are being exploited through clinical trials at Dr Habeebulah Life Sciences under appropriate guidelines
• Different types of stem cells serve different purposes in the body which are being explored at this centre.
• The same stem cell treatment is unlikely to work for different diseases or conditions, hence different sort of stem cells are being evaluated for their specific role in each condition.
• The processes are being developed through which stem cell science has been turned into regenerative medicine by minimizing the harm and maximize the effectiveness in disease conditions.

Futuristic view of stem cell-based treatment possibilities in patient’s welfare  

Dr Habeebullah Life Sciences provides its two decades scientific experiences about the benefits of stem cell-based treatment possibilities or positive relevance such as:

• It can bridge the liver transplantation
• Cost-effectiveness
• Comparatively less invasive procedures for stem cells transplantation
• Highly reduced post-transplantation complications
• No need of life-long immunosuppessive therapy
• Improves quality of life

Dr Habeebullah Life Sciences offers well standardized and proven technologies to implement stem cell-based treatment strategies. Improvement are being continuous made in cell delivery techniques for better engraftment of transplanted cells and tools/ biomarkers for tracking of transplanted cells to identify their fate post-transplantation. Under one roof, the centre provides better feasibility to convey the technology in better and scientific way. It also facilitates the organ regeneration strategies to support the patient both scientifically and economically.

Much of the interest in stem cell-based therapies in India appears focused on patient need, particularly the growing national burden of chronic diseases for which stem cell therapies will offer promising solutions.

To address current barriers to this sector, Dr Habeebullah Life Sciences has increase integration between researchers and clinicians, foster high-quality education and training, increase public awareness, and secure adherence to its new stem cell regulatory framework.

By taking additional steps in this direction, Dr Habeebullah Life Sciences intends to improve the health of its population but is likely to become one of the main contributors to the emerging potential field of stem cells and regenerative medicine.

The Contract Research Organization(CRO) division is located in MN Park, Hyderabad, India.

It aims to be the best in Contract Research and Manufacturing Services(CRAMS), committed to serve the pharmaceutical industry worldwide with high quality standards at par with the international regulatory and professional expectations.

The division is actively involved in developing Non-infringing processes for API’s keeping the cost reduction and environment friendly process.

This division is focused on building expert core capabilities in Synthetic Chemistry, Medicinal Chemistry, Drug Development, API’s process research, scale up activity, Natural products research and Analytical services.

Established by professionally qualified and highly efficient team, the research is well experienced in design of the new molecules, API’s process development from gram to kilogram scale, structure elucidation, impurity profile studies, process validation and process optimization. The Organizations world class management team is composed of highly experienced executives and the distinguished members of the Scientific Advisory Board (SAB) helping to attain our high standards of Science and execution.

The division’s technical expertise and infrastructure can deliver diverse chemistries from gram to kilogram scale. This enables the Company to partner with biotech and pharma companies throughout the lifecycle of the product.

Apart from routine organic chemical transformations, the Company’s chemistry range includes: Multi-step synthesis, Cryogenic reactions, heterocyclic chemistry, Suzuki Coupling, Heck coupling, Sonogashira coupling, Amide Coupling, Nitrations, Chlorinations, Sodium metal handling, Diazotization, Chiral Chemistry.

We recently filed one non-infringing patent application for “Sorafenib Mesylate” (Patent App. No. 201741031517 dated 6^th Sept 2017).

Currently, this division is developing few API molecules from R&D to plant level.

Few molecules completed R&D and pilot plant work. Plant batches (Scale up) work is in progress (under discussions). The molecules are as follows:

Anti-Cancer:

• Sorafenib
• Regorfenib
• Imatinib mesylate
• Erlotinib
• Nilotinib
• Nintedanib
• Sunitanib
• Bendamustan

Anti HIV agent:

• Dharunavir
• Fosamprenavir

Hypertension and Cholestrol lowering Agent

• Azil Sartan

Anti-Diabetic molecule

• Vildagliptin

HLS boasts of highly accomplished Board of Directors, management and technical teams with eminent doctors and scientists on board. The Company aspires to establish training institutes to impart the culture of advanced research and innovation amongst the budding scientific community in the state and the nation.

Download Brochure